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ati pain and inflammation test

While you may not be able to avoid the pain that comes with rheumatoid arthritis (RA), you can take action to limit it. Start with these eight ideas:

SOURCES:
American College of Rheumatology: “Position statement on ‘complementary’ and ‘alternative’ therapies for rheumatic diseases,” 1998.
American College of Rheumatology Ad Hoc Committee on Clinical Guidelines, Arthritis and Rheumatism, 2002.
Arthritis Foundation: “Pain Center.”
Horstman, J. The Arthritis Foundation Guide to Alternative Therapies, Arthritis Foundation, 1999.
Lee, D. The Lancet, Sept. 15 2001.
Lorig, K. British Journal of Rheumatology, 1995.
Miller, R. Miller’s Anesthesia, 6th ed., Elsevier/Churchill Livingstone, 2004.

Sources

Safety and effectiveness in pediatric patients below the age of 18 years have not been established.

Elderly patients may be more sensitive to the antiprostaglandin effects of NSAIDs (on the gastrointestinal tract and kidneys) than younger patients (see WARNINGS). In particular, elderly or debilitated patients who receive NSAID therapy seem to tolerate gastrointestinal ulceration or bleeding less well than other individuals, and most spontaneous reports of fatal GI events are in this population.

NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. The mean minimum lithium concentration increased 15% and the renal clearance was decreased by approximately 20%. These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.

Excretion

Etodolac has no apparent pharmacokinetic interaction when administered with furosemide or hydrochlorothiazide. Nevertheless, clinical studies, as well as post marketing observations have shown that etodolac can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for sings of renal failure (see WARNINGS, Renal Effects ), as well as to assure diuretic efficacy.

The mean oral clearance of etodolac following oral dosing is 49 (± 16) mL/h/kg. Approximately 1% of an etodolac dose is excreted unchanged in the urine with 72% of the dose excreted into urine as parent drug plus metabolite:

There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. The concurrent use of aspirin and an NSAID does increase the risk of serious GI events (see WARNINGS, Gastrointestinal EffectsRisk of Ulceration, Bleeding, and Perforation).

Safety and effectiveness in pediatric patients below the age of 18 years have not been established.