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cannabis research studies

The journal is an official publication of the Institute of Cannabis Research at Colorado State University-Pueblo.

Authors: Eric Murillo-Rodríguez, Diana Millán-Aldaco, Gloria Arankowsky-Sandoval, Tetsuya Yamamoto, Roger G. Pertwee, Linda Parker and Raphael Mechoulam

13 February 2020

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Authors: Omayma Alshaarawy

Our journal welcomes all aspects of cannabis research, divided into the following sections:

Authors: Rabia Khan, Sadiq Naveed, Nadeem Mian, Ania Fida, Muhammad Abdur Raafey and Kapil Kiran Aedma

Content type: Original research

Many athletes are turning to cannabis to improve performance, enhance pleasure, and aid recovery. However, and in contradiction with the Reefer Madness-era propaganda, cannabis has traditionally been conceptualized as making people lazy.

For instance, tremors are a core symptom in Parkinson’s disease that can be exacerbated during periods of stress, and it was proposed that CBD’s anxiety and stress-reducing effects may help dampen tremors. To test this, Brazilian scientists conducted a double-blinded placebo-controlled trial of CBD with Parkinson’s disease patients during a simulated public speaking test. Using an accelerometer to measure tremor size, they found that a single dose of 300mg CBD reduced both anxiety and tremor compared to the placebo. These results suggest that CBD may be helpful in dampening tremor in Parkinson’s disease patients during stressful situations.

One study found that a 48:1 THC:CBD oil delivered sublingually via tincture substantially improved the quality of life for women suffering from fibromyalgia, a form of chronic pain that is notoriously difficult to treat. These patients consumed an average of 4.4 mg THC per day and reported that their pain was cut in half, their ability to perform at work improved, and their mood robustly improved compared to those who received a placebo. This highlights the promising effects of only a moderate THC dose in treating this debilitating condition.

THC doesn’t make you lazy

Here are some of the top stories in cannabis research in 2020. (And for the record, the student was granted an extension.)

This suggests that motivation can decrease with frequent use of THC-rich cannabis. But for periodic consumers, it looks like a couple of hits won’t keep you from wanting to put in the miles.

However, the study authors found that genetically eliminating a mouse’s CB1 receptors did reduce their preference to run. This is important because excessive THC consumption can cause a tolerance, which one experiences as a weakening of THC’s effects, and is associated with the reduction in CB1 receptors.

The holy grail of a cannabinoid-based drug would be one designed to treat neurodegenerative disorders and pain, and to also provide neuroprotection, by selectively activating CB2 receptors without activating CB1 receptors, enabling the benefits of dampening inflammation without causing a high. To do so, drug designers need to know what both these receptors look like when resting and when activated. The problem: They’re really small.