In 2018, in a study of more localized treatment, researchers administered a synthetic CBD gel in either 250-milligram or 500-milligram doses daily or a placebo to patients with knee pain due to osteoarthritis. Patients also stopped taking any other anti-inflammatory medications or painkillers, with the exception of acetaminophen, before and during the study period.
In a small 2018 study in the Journal of Alternative and Complementary Medicine, 11 people with post-traumatic stress disorder (PTSD) received CBD along with routine psychiatric care for eight weeks in an outpatient psychiatric clinic. Ten of the 11 experienced a decrease in their PTSD symptoms. CBD was generally well tolerated, the researchers write.
Meanwhile, at least one study in mice revealed CBD had effects similar to the antidepressant imipramine. Human trials are needed, though, to confirm whether CBD can induce this same antidepressant reaction in our bodies.
9. Inhibit Arthritis Symptoms
Meanwhile, continued studies in the U.S. indicate CBD is effective in treating chronic, non-cancer pain. In one 2020 study, researchers administered CBD topically to a group of patients with symptomatic peripheral neuropathy (a result of brain nerve and spinal cord nerve damage) while another group with the same condition received a placebo. Results showed a significant reduction in intense, sharp pains and cold, itchy sensations in those who used the topical CBD compared to those who used the placebo. No participants reported adverse side effects.
Margaret Rajnic, a doctor of nursing practice experienced in medical cannabis and CBD, emphasizes the importance of using therapy in tandem with any type of cannabis or CBD for PTSD. “There is an amount of therapy that is needed for PTSD,” she says. “But CBD will give you that little bit of decreased anxiety.”
In 2005, Canada approved the use of Sativex, an oromucosal (absorbed in the lining of the mouth) spray with equal proportions of THC and CBD, for the treatment of multiple sclerosis-related central neuropathic pain. In 2007, Canada approved the medicine’s use again for cancer pain that proved unresponsive to other medications.
Several preclinical studies suggest CBD can produce beneficial effects against Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. Huntington’s disease and cerebral ischemia were also tested, although significant positive results were not recorded. Further clinical studies are needed to confirm CBD’s benefits when used as a treatment for these disorders.
Luckily, the Farm Bill also preserved the oversight of products derived from cannabis to the Food and Drug Administration  .
Hence, though CBD and THC share almost the exact formula, they have a difference in the molecular structure that gives every compound unique medicinal properties. CBD has a hydroxyl group while THC has a cyclic ring that gets you high, while CBD, on the other hand, does not. Hence, CBD can moderate the effects of THC  by alleviating anxiety and stress, giving you clarity and not high.
Is CBD Legal?
GI secretion, propulsion, and inflammation in the human gut are modulated by the ECS (Endocannabinoid System), which makes it rational for IBS treatment candidates to consider CBD. Unfortunately, at the same time, many patient reviews have indicated the benefits of CBD when A treating IBS symptoms  , and there is a lot of anecdotal support on the internet. There is little clinical work to establish that CBD can help relieve IBS symptoms. However, the modulation of the gut ECS may help provide a useful therapeutic target for IBS.
Subjects who had taken CBD had lowered blood pressure both before and after stress, increased heart rate, and decreased stroke volume. In response to cold stress, those who received CBD had blunted blood pressure and an increased heart rate with lower total peripheral resistance.
Antipsychotics work by targeting the release of neurotransmitters in the brain, such as acetylcholine, noradrenaline, serotonin, and dopamine. Excess dopamine causes psychotic symptoms, and so antipsychotic medication helps bind dopamine receptors to reduce dopamine production.