There is some evidence that CBD interacts with seizure medications such as Onfi (clobazam) and boosts their concentration in the blood. Further research is needed.
Instead, CBD is thought to influence other receptors, including opioid receptors that regulate pain and glycine receptors involved in the regulation of the “feel-good” hormone and neurotransmitter serotonin.
Outside of these two disorders, CBD’s effectiveness in treating seizures is uncertain. Even with Epidiolex, it is uncertain whether the anti-seizure effects can be attributed to CBD or some other factor.
Possible Side Effects
To use CBD oil, place one or more drops under the tongue and hold the dose there for 30 to 60 seconds without swallowing. Capsules and gummies are easier to dose, although they tend to be more costly. CBD sublingual sprays are available as well.
As CBD grows in popularity, so does the research on it but there are currently few clinical studies on the effects of CBD oil. As such, some of these claims are better supported by studies than others.
Among the few human trials evaluating CBD’s anxiolytic effects was one published in the Brazilian Journal of Psychiatry in 2019. For this study, 57 men were given either CBD oil or a placebo before a public-speaking event. Anxiety was evaluated using physiological measures (such as blood pressure, heart rate, etc.) and a relatively reliable test for mood states known as the Visual Analog Mood Scale (VAMS).
CBD oil may also increase liver enzymes (a marker of liver inflammation). People with liver disease should use CBD oil with caution, ideally under the care of a doctor who can regularly check blood liver enzyme levels.
Hemp oil is made from hemp seeds. In one serving of hemp seeds (3 tablespoons), you’ll find the following:
Some people experience skin irritation when using topical oils containing CBD, possibly due to an allergy. Start with using a small amount to see how your skin reacts to it, and keep an eye on any changes.
Journal of Clinical Investigation: “Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.”
Hemp seeds also contain these minerals and hemp nutrients:
The amino acid arginine is present in hempseed oil. Studies have shown that this ingredient contributes to a healthy cardiovascular system. Consuming foods with high arginine levels can help decrease the risk of heart disease.
Brain, Behavior, and Immunity: “Omega-3 Supplementation Lowers Inflammation and Anxiety in Medical Students: A Randomized Controlled Trial.”