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cbd meaning

Harlequin : This cultivar was bred by crossing classic landraces from Nepal, Switzerland, and Thailand. Its consistent 5:2 CBD to THC ratio ranks it among CBD-rich staple cultivars.

(Photo by: Gina Coleman/Weedmaps)

The scientists behind this study noticed that researchers had been utilizing pure, single-molecule CBD, which resulted in a bell-shaped dose-response curve. This curve indicates that CBD’s efficacy plummets at very high and very low doses.

Single compound vs. whole plant

The relationship between THC and CBD is complex, but in short, CBD appears to minimize some of THC’s less desirable effects, such as paranoia , heart palpitations, and impaired thinking. A combination of THC and CBD may offer enhanced therapeutic value to patients . This phenomenon of cannabis-derived molecules working more synergistically together than they do in isolation is commonly referred to as the entourage effect .

Flower : Combusting or vaporizing CBD weed allows users to feel the potential therapeutic effects of CBD almost immediately.

CBD has some other very important roles outside the ECS. For instance, CBD mildly activates one of the brain’s predominant serotonin receptors (5-HT1A) in mice, which may explain its supposed effects on depression and anxiety . It also acts at the peroxisome proliferator-activated receptors (PPARs) in mice, which may indicate its usefulness in fighting inflammation.

CBD fits the definition of a psychoactive substance as it can subtly alter perception and mood. However, it’s important to reiterate that unlike weed, CBD does not cause intoxication. CBD is a non-intoxicating substance, so it cannot stimulate the level of sensory and psychological effects that THC does.

Long LE, Chesworth R, Huang XF, et al. A behavioral comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice. Int J Neuropsychopharmacol 2010;13(7):861-76. View abstract.

McGuire P, Robson P, Cubala WJ, et al. Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial.Am J Psychiatry. 2018;175(3):225-231. View abstract.

Zuardi AW, Crippa JA, Hallak JE, et al. Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug. Braz J Med Biol Res 2006;39(4):421-9. View abstract.

Special Precautions and Warnings

Cunha, J. M., Carlini, E. A., Pereira, A. E., Ramos, O. L., Pimentel, C., Gagliardi, R., Sanvito, W. L., Lander, N., and Mechoulam, R. Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology 1980;21(3):175-185. View abstract.

Chesney E, Oliver D, Green A, et al. Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials. Neuropsychopharmacology. 2020. View abstract.

Watzl, B., Scuderi, P., and Watson, R. R. Marijuana components stimulate human peripheral blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha in vitro. Int J Immunopharmacol. 1991;13(8):1091-1097. View abstract.

Rosenkrantz H, Fleischman RW, Grant RJ. Toxicity of short-term administration of cannabinoids to rhesus monkeys. Toxicol Appl Pharmacol 1981;58(1):118-31. View abstract.

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a situation in which older and younger people do not understand each other because of their different experiences, opinions, habits, and behaviour