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cbd medical condition

Lee SE, Rabinovici GD, Mayo MC, et al. Clinicopathological correlations in corticobasal degeneration. Ann Neurol. 2011;70:327-340.

Clinical Testing and Work-Up

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Investigational Therapies

Contact for additional information about corticobasal degeneration:

San Francisco, CA 94158

Imaging techniques such as computerized tomography (CT) scanning and magnetic resonance imaging (MRI) may be used to rule out other conditions or reveal characterized brain tissue degeneration within the cerebral cortex and basal ganglia. During CT scanning, a computer and x-rays are used to create a film showing cross-sectional images of certain tissue structures including the brain. An MRI uses magnetic field pulses to produce cross-sectional images of particular organs and bodily tissues such as the brain.

Corticobasal degeneration is believed to affect males and females in equal numbers. However, in some studies it was reported to be more common in women. Symptoms usually begin between the ages of 50-70. No confirmed cases of corticobasal degeneration have been reported in the medical literature in individuals under 40. The disorder is estimated to affect 5 people per 100,000 in the general population, with approximately .62-.92 new cases per year per 100,000 people. However, cases may go undiagnosed or misdiagnosed making it difficult to determine the true frequency of corticobasal degeneration in the general population.

CBD occurs when cells in specific parts of the brain – the cortex and basal ganglia – are damaged as a protein called tau builds up and over time causes harmful clumps. In normal brains, tau is broken down to avoid a build-up, but in CBD this does not happen.

Speech and communication problems: slow and slurred speech.

We would like to thank Prof Carlo Colosimo (Università La Sapienza, Rome, Italy) for his help in reviewing this infomation.


Diagnosis is usually based on the pattern of symptoms experienced and the exclusion of other conditions that may cause similar symptoms, such as Parkinson’s or stroke. Unfortunately, as with Parkinson’s, there is no single test or scan to diagnose CBD.

A diagnosis should be made by a specialist with experience in CBD, usually a neurologist. He or she may ask for a brain scan to rule out other causes, and they may also carry out tests to check memory, concentration, and understanding of verbal communication.

Movement difficulties

CBD is a very individual condition and the symptoms each person experiences vary. As CBD is a progressive neurodegenerative condition, symptoms gradually become worse over time.