Instead of adding CBD to an antidepressant regimen, it may be more ideal for you to be able to stop using your antidepressants altogether. If you would like to try CBD oil in place of antidepressants, there are some important things you should consider.
CBD oil has been found to inhibit the CYP3A4 and CYP2D6 enzymes. This means it has the potential to interact with many medications by reducing their metabolism and increasing the amount of medication circulating in the body. Many antidepressants are metabolized by the CYP2D6 enzyme, so their clearance from the body could be reduced by the use of CBD oil. It is still unclear is how significant this interaction is; it is not completely understood if this interaction is related to the dose of CBD oil ingested or related to the route of ingestion of the product.
While CBD is a more natural product, it carries certain risks that are not seen with antidepressants. One of the biggest risks with using these products is their current lack of regulation. Because CBD oil is sold online and in stores, there is little to no regulation controlling the quality of the products being marketed and sold. This lack of regulation and standardization makes these products harder to dose for different indications.
Can CBD Replace Antidepressants?
Much of the current research into the use of CBD in depression has been in animals. However, studies have evaluated the mechanism of CBD in the treatment of depression. CBD is known to act on the endocannabinoid system to reduce pain symptoms. Researchers have also begun to study the effect of antidepressants on this system to reduce symptoms of depression. This research has also discovered the impact of other receptors and areas of the brain that are affected by both antidepressants and CBD. This developing research suggests that CBD’s activity in the brain could improve depression, but more investigation into this indication is needed.
With evidence suggesting CBD oil may benefit those who suffer from anxiety or depression, many people wonder if supplementing their antidepressant therapy with CBD oil is a safe and effective option.
Finally, stopping antidepressants can be a challenging task. Reducing or stopping antidepressants cause withdrawal symptoms, such as those listed above, which may discourage some people from effectively making this transition. Stopping these medications too early or too quickly can also cause you to experience worsening anxiety or depression symptoms. To be safe, this process must be carefully executed and closely monitored by a physician or other qualified psychiatric care provider.
Preparation is important before deciding to stop taking antidepressants in favor of CBD oil. First, evaluate your current antidepressant regimen. If you are taking antidepressants, these are best stopped by titrating down the dose before quitting them all-together. If you have multiple antidepressants, talk to your physician about how to slowly decrease and remove these medications; it will be a better transition if you decrease one medication at a time. This process may be slow, but it will reduce withdrawal symptoms and improve your chance for a successful transition to CBD oil.
The cytochrome P-450 system, found in the liver, breaks down medications into smaller substances that the body can more easily process. There are a range of natural foods and compounds that slow down this system, including grapefruit, St. John’s Wort, and of course, cannabidiol (CBD). When the system is inhibited, some medications, like monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs), remain in the system for a longer period, increasing the chance you will experience some of their unpleasant side effects.
To find information on CBD dosage, including how to find the right starting dose for your needs, read the CBD Oil Dosage Guide. You can also get more personalized help by speaking with a naturopathic doctor who specializes in using CBD oil to treat medical conditions.
Interactions Between CBD and Antidepressants
To learn more about taking CBD to manage depression, head over to our guide: Depression and CBD Oil: Benefits, Effectiveness, and Dosage.
If you’ve considered transitioning from antidepressants to CBD oil, or are thinking about combining the two, here’s what you need to know.
While CBD oil is generally well-tolerated and taken without side-effects, there are a few medications which, when used with CBD oil, can create adverse reactions. These interactions occur because CBD oil inhibits the cytochrome P-450 enzyme system.