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cbd oil and liver enzymes

“Patients with hepatitis C who used cannabis had way more liver scarring than those who didn’t and more progression of their liver disease. Something in the cannabis could actually be increasing fatty liver disease,” Dr. Hardeep Singh, gastroenterologist at St. Joseph Hospital in Orange, California, told Healthline.

Shockingly, researchers discovered that the mice given higher doses of CBD showed signs of liver damage within 24 hours. To that end, 75 percent of these animals in the sub-acute phase had either died or were on the verge of death within a few days.

The latest study also finds that CBD has the potential for herbal and drug interactions. “CBD differentially regulated more than 50 genes, many of which were linked to oxidative stress responses, lipid metabolism pathways and drug metabolizing enzymes,” the study reads.

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Since then, CBD, a substance often touted as being safer than popping pills, has become highly revered as an alternative treatment for a variety of common ailments from anxiety to chronic pain. But a new study suggests that CBD may spawn its fair share of health issues. Specifically, scientists have learned that this substance could be damaging our livers in the same way as alcohol and other drugs.

The photo of liver is on the man’s body against gray background, Liver disease or Hepatitis, Concept . [+] with body problem and male anatomy

But wait, it gets worse.

Researchers then spent some time examining mice under the influence of various doses of CBD. Some of the animals received lower doses, while others were given more. The dosage is said to have been “the allometrically scaled mouse equivalent doses (MED) of the maximum recommended human maintenance dose of CBD in EPIDIOLEX (20 mg/kg).”

The FDA adds, “There are no other FDA-approved drug products that contain CBD. We are aware that some firms are marketing CBD products to treat diseases or for other therapeutic uses, and we have issued several warning letters to such firms.”

Potentially, yes. In both clinical trials for the FDA-approved CBD-centric drug Epidiolex, anywhere from 5 to 20 percent of patients experienced elevated liver enzymes. In a different study conducted on lab mice, mice treated with higher concentrations died or were near death within 24 hours of ingesting the CBD.

Can CBD Cause Liver Damage?

While the long-term effects of ingesting CBD oil are relatively unknown at this point in time, it’s not just human health that people are worried about. In the aftermath of the 2018 Farm Bill legalized CBD oil, many pet-oriented companies have put CBD products on their shelves and readily marketed CBD as a prospective treatment for dogs enduring chronic pain, anxiety, and other issues. Knowing what we know about how the CBD in Epidiolex affected the liver of mice and humans, can CBD also cause liver damage in dogs?

It’s also worth noting that the label on Epidiolex explicitly states that liver damage could be a side effect of taking this epilepsy medication. According to an interview with Dr. Igor Koturbash, Ph.D., the Epidiolex label “clearly states a warning for liver injury. It states that you have to monitor the liver enzyme levels of the patients. In clinical trials, 5 percent to 20 percent of the patients developed elevated liver enzymes.”

According to Medical News Today, CBD oil is commonly used in treating chronic pain, epilepsy, Huntington’s disease, glaucoma, Parkinson’s disease, and a myriad of sleep disorders. Studies have noted its ability to help mitigate pain associated with cancer, as well as its use as an anti-cancer drug. A review published in Neurotherapeutics found a link between the reduction of anxiety-related behaviors in people with anxiety disorders and CBD. It also found CBD could potentially reduce symptoms for people with related anxiety disorders including general anxiety disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, and social anxiety disorder.