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cbd oil dry mouth

The researchers found that the endocannabinoid agonist anandamide (AEA) binds with high affinity to the glandular cannabinoid receptors and blocks the action of the saliva-inducing compounds norepinephrine and methacholine, leading to a decrease in the secretion of saliva.

The researchers hypothesized that intravenous administration of cannabinoids via the femoral vein not only exerted their primary effect via the submandibular glands, but may also have acted on the cannabinoid receptors in the brain itself. They argued that a central nervous system mechanism helps to control production of saliva at glandular level.

For more complete relief, using a demulcent (a substance that coats a mucous membrane with a moist ‘film’) designed for oral use should suffice. Many different prescription medications can cause users to experience dry mouth, so there are numerous oral demulcents commercially available to combat the problem.

CB-receptors in the salivary glands

Cannabis users all over the world are sure to be familiar with that sticky, dry, pasty sensation that affects the mouth after smoking cannabis. In fact, it is so inevitable that people rarely question the mechanism at work behind this strange little phenomenon—except for a handful of researchers who believe they know why it happens.

Experiencing a dry mouth and throat after cannabis use is extremely common, and often it does not take much cannabis to induce this effect. However, during a heavy session, the dry-mouth effect can often increase until it becomes extremely unpleasant.

First, we should take a brief look at the process of saliva production. It appears that saliva formation involves a two-stage process. Initially, specialised cells known as acinar cells secrete a fluid that is similar in composition to plasma. This fluid then passes through the salivary ducts on its way to the oral cavity, and as it does so, sodium and chloride are removed from it and potassium and bicarbonate are added to it. This process is what produces the final ‘hypotonic solution’ that is secreted into the mouth.

Secretion of saliva is controlled by the parasympathetic nervous system (PSNS). The PSNS is responsible for various metabolic processes related to food intake, appetite, and anticipation of eating.

The most comment side effects of CBD include drowsiness, gastrointestinal issues, dry mouth, reduced appetite, nausea, and interaction with other medications. Those are outlined in detail below.

CBD is technically an unregulated substance in the United States and therefore it ought to be used with caution. This is especially important for those taking additional medications and/or those with ongoing medical issues. That said, preliminary research on CBD and its benefits are promising in relation to helping with mild to moderate health concerns and it is generally considered a safe substance. Health professionals do not consider CBD a cure-all for serious medical issues, including cancer.

Drowsiness

“Since discovering the endocannabinoid system (ECS) in the body in the 1990s, CBD has been researched more extensively. The ECS is a central regulatory system restoring normal balance and homeostasis in a range of human physiologic systems throughout the body and brain and has cannabinoid receptors and chemicals in its function,” explains Dr. Matharu-Daley.

She adds, “[Another difference is that] CBD is derived from hemp and has been classified as a legal substance. Hemp has <0.3% THC. Conversely, cannabis plants such as marijuana are grown to have much higher levels of THC and are still illegal according to the FDA, although individual states vary as to their use.”

CBD is one of the many chemical compounds that is found in the cannabis plant—referred to as cannabis sativa. There are two primary parts of the plant that humans use. One is THC, or Delta-9-Tetrahydrocannabinol, and the other is CBD. Though they’re from the same plant, THC and CBD are quite different from each other.

This review paper on the Safety and side effects of cannabidiol 1 by the NCBI for example suggests that controlled cannabidiol administration is safe and non-toxic in humans and animals. It also does not induce changes in food intake; nor does it affect physiological parameters like heart rate, body temperature or blood pressure. Also, according to this review paper, “high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans.”

In higher doses, CBD can cause drowsiness. If you are affected this way, you should not operate machinery or drive a vehicle. In most cases however, CBD is a wake-inducing agent.

1. Inhibition of hepatic drug metabolism

Higher doses of CBD oil can cause a small drop in blood pressure , usually within a few minutes of the CBD entering your system. This drop in blood pressure is often associated with a feeling of lightheadedness. If you are taking medication for blood pressure, you should consult your doctor before taking CBD.

Early research suggests that CBD taken in high doses may worsen tremor and muscle movement in Parkinson’s disease sufferers. Yet, there are also studies that suggest that cannabidiol is safe and well-tolerated by patients affected by this condition. If this occurs, reducing the dose should reduce this potential side effect. Parkinson’s disease sufferers should consult their doctor before taking CBD and also begin any regimen by taking smaller doses.

Putting this in perspective, eating a portion of grapefruit would have a similar effect on the aforementioned liver enzymes. So this should be viewed as a minor side effect of cannabidiol. However, if you are taking pharmaceutical drugs and wish to take CBD, you should discuss any potential complications regarding reduced P450 enzyme activity with your doctor and/or pharmacist.