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cbd oil epilepsy dogs

No adverse behavioral effects were reported by owners.

So McGrath asked herself, “Could we be doing the research?”

NEWStat spoke with McGrath about the findings and asked her what she thought of CBD as a potential treatment for canine epilepsy.

“We’re dying for dogs,” McGrath says, and notes that the trial is fully funded, “so it won’t cost dog owners anything.” She says her team will work with other neurologists and veterinarians to help collect blood samples and make the process of participating “as easy as possible.”

Her interest in the hemp byproduct was sparked when she started hearing anecdotal stories about the successful use of CBD in treating adult and pediatric epilepsy. When pet owners and veterinarians started calling her to ask if she knew of any studies going on at CSU about the use of CBD to treat pets, she started checking around: “Across the board, people were saying no.” They’d heard the anecdotal stories, McGrath said, but no one was doing the research.

In fact, they’ve already begun. And they need more dogs.

Turns out the answer was yes.

Procedures: Dogs were randomly assigned to a CBD (n = 12) or placebo (14) group. The CBD group received CBD-infused oil (2.5 mg/kg [1.1 mg/lb], PO) twice daily for 12 weeks in addition to existing antiepileptic treatments, and the placebo group received noninfused oil under the same conditions. Seizure activity, adverse effects, and plasma CBD concentrations were compared between groups.

Results: 2 dogs in the CBD group developed ataxia and were withdrawn from the study. After other exclusions, 9 dogs in the CBD group and 7 in the placebo group were included in the analysis. Dogs in the CBD group had a significant (median change, 33%) reduction in seizure frequency, compared with the placebo group. However, the proportion of dogs considered responders to treatment (≥ 50% decrease in seizure activity) was similar between groups. Plasma CBD concentrations were correlated with reduction in seizure frequency. Dogs in the CBD group had a significant increase in serum alkaline phosphatase activity. No adverse behavioral effects were reported by owners.

Objective: To assess the effect of oral cannabidiol (CBD) administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with idiopathic epilepsy.

Animals: 26 client-owned dogs with intractable idiopathic epilepsy.

Design: Randomized blinded controlled clinical trial.

Conclusions and clinical relevance: Although a significant reduction in seizure frequency was achieved for dogs in the CBD group, the proportion of responders was similar between groups. Given the correlation between plasma CBD concentration and seizure frequency, additional research is warranted to determine whether a higher dosage of CBD would be effective in reducing seizure activity by ≥ 50%.