Posted on

cbd oil for borderline personality disorder

The World Health Organization states that cannabis is the most common illicit substance, with around 147 million users worldwide. Therefore, it makes sense that there is a lot of overlap between cannabis use and borderline personality disorder.

BPD is difficult to treat and does not respond well to medication. The most successful BPD treatments include talk therapy and group therapy. One of the most effective therapies is a treatment called dialectical behavioral therapy (DBT).

What Is Borderline Personality Disorder?

Cannabis has significant effects on both the body and mind, which stem from its interaction with the human endocannabinoid system (ECS). The ECS comprises cell receptors known as cannabinoid receptors and chemicals called endocannabinoids.

Therefore, it may be safer for BPD patients to choose a low THC and high CBD marijuana strain. They may even prefer to opt for CBD oil.

Experts believe BPD may be a result of a combination of genetic and environmental factors. It tends to affect people who had a disrupted, traumatic, or abusive childhood or to people who may have experienced abandonment at an early age.

Borderline Personality Disorder (BPD) is a chronic debilitating psychiatric disorder characterized mainly by emotional instability, chaotic interpersonal relationships, cognitive disturbance (e.g., dissociation and suicidal thoughts) and maladaptive behaviors. BPD has a high rate of comorbidity with other mental disorders and a high burden on society. In this review, we focused on two compromised brain regions in BPD – the hypothalamus and the corticolimbic system, emphasizing the involvement and potential contribution of the endocannabinoid system (ECS) to improvement in symptoms and coping. The hypothalamus-regulated endocrine axes (hypothalamic pituitary – gonadal, thyroid & adrenal) have been found to be dysregulated in BPD. There is also substantial evidence for limbic system structural and functional changes in BPD, especially in the amygdala and hippocampus, including cortical regions within the corticolimbic system. Extensive expression of CB1 and CB2 receptors of the ECS has been found in limbic regions and the hypothalamus. This opens new windows of opportunity for treatment with cannabinoids such as cannabidiol (CBD) as no other pharmacological treatment has shown long-lasting improvement in the BPD population to date. This review aims to show the potential role of the ECS in BPD patients through their most affected brain regions, the hypothalamus and the corticolimbic system. The literature reviewed does not allow for general indications of treatment with CBD in BPD. However, there is enough knowledge to indicate a treatment ratio of a high level of CBD to a low level of THC. A randomized controlled trial investigating the efficacy of cannabinoid based treatments in BPD is warranted.

Keywords: Borderline personality disorder; cannabidiol; corticolimbic system; endocannabinoid system; hypothalamus; pharmacological treatment.

Among the endocannabinoid receptors that CBD activates are 5-HT1A serotonin receptors. Serotonin, informally known as the “happy chemical,” a chemical the body produces that’s important for mood regulation. People suffering from depression and anxiety, for instance, seem to exhibit lower levels of serotonin than do people who are not. People with BPD exhibit the same lowered serotonin levels. When CBD activates the 5-HT1A serotonin receptors, they bind to 5-HT serotonin neurotransmitters and increase serotonin production, which, in turn, combats the negative effects of depression and anxiety that come along with BPD.

Endocannabinoids are sent throughout the body by the ECS to achieve and maintain the body’s internal homeostasis, or balance, among all of is working parts. In many psychiatric disorders, symptomatic or episodic behaviours can be traced back to overactive neurons, which send too many neurotransmitters from presynapse to postsynapse and overload receptors.

People with BPD exhibit most or all of the following symptoms:

Article content

Because BPD is a personality disorder, treatment options are limited. Behavioural therapies like cognitive behavioural therapy (CBT) and dialectical behavioural therapy (DBT) are the most effective treatment options for BPD. There are no medications designed specifically for BPD, but antidepressant, anti-anxiety and antipsychotic medications are often prescribed to BPD patients to address certain symptoms like depression, anxiety, dissociation, paranoia and intense anger. The benefit of these medications for people with BPD, however, remain unclear, and talk-therapy is often the first line of treatment for BPD.

TheFreshToast.com, a U.S. lifestyle site, that contributes lifestyle content and, with their partnership with 600,000 physicians via Skipta, medical marijuana information to The GrowthOp.

Since endocannabinoids follow the inverse of this process, they actually block and mediate the transfer of neurotransmitters to ensure the appropriate amount of neurotransmitters are being sent and binding to receptors. And, since the plant-derived cannabinoids that enter your body when you use CBD act like the endocannabinoids your body produces, they also work to mitigate the transfer of neurotransmitters and to combat overactive neural transfer associated with many of the BPD symptoms like anxiety, anger, impulsivity and even paranoia.

Approximately 1.6 percent of adults in the U.S. suffer from borderline personality disorder (BPD), a condition characterized by difficulty regulating emotions, impulsivity, low self-image and problems creating and maintaining personal relationships.