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cbd oil for hs

The participants will be randomly assigned in a 1:1 ratio to receive Avidekel oil or placebo oil. Patients will receive the oils as drops applied under the tongue 3 times a day.

When the patient license arrives, the patient will be scheduled an appointment for the first visit of the trial at the hospital. Tikun-Olam will be informed and asked to supply the patient product on the visit day. The copy of the patient’s license will be included into the trial source documents.

The YAKAR form of medical cannabis license application and a confidentiality waiver form will be sent to the YAKAR. The physician will explain to the patients that his/her participation in the trial can be terminated at any time and will explain the medical license conditions: It is absolutely forbidden to:

Forty participants will be recruited over two years. After determine eligibility by examining the study criteria for inclusion and exclusion, the patient will be asked to sign the informed consent form.

The duration of study participation for each subject is expected to be 12 weeks (84 days), about 4 weeks from visit 0 until receiving the license and 8 weeks trial,of which, six weeks of dose titration. Over the course of twelve weeks, four visits will be conducted and there will be 3 telephone evaluations. During first visit screening and enrolment will be conducted. The second visit will take place four weeks later where patients will receive the oils and start the trial, followed by a phone call evaluation at day 5-7 after starting the treatment and at week 2±2 days. Than a visit approximately four weeks later, following another phone call evaluation at week 5±2 days from treatment beginning, F Last visit will be conducted at week 8±3 days. In each visit, the relevant variables will be collected (Please refer to Table 3. Schedule of events). At the end of the eight-week experiment, patients from the treatment and control groups will be given the option to use the Avidekel oil for a period of one year. First, all the patients will use the drug in the open label phase for 8 weeks, during this period 3 phone calls and 2 visits in the hospital will be conducted, using PI-NRS and HS-PGA score to evaluate treatment success. Patients who will have at least 1 point reduction on the HS-PGA score will be permitted to continue to the 1 year follow-up. During that period 2 visits, six months and one year, will be conducted and the relevant variables will be collected (see Table 3). All visits will take place at the hospital.

Mandy was referred to a surgeon in November 2013, and was told invasive surgery would be needed to stop the HS, as it has now deeply penetrated the skin. She declined the surgery due to the risks. Prior to this, Mandy had done some research on the potential of cannabis to treat her condition, and had also been smoking it to treat pain.

In 2010, her condition worsened causing significant pain, infectious issues, and bleeding concerns. From this point and for the next two years, Mandy tried numerous medications and surgery, all of which failed to stop the disease from progressing to Stage 3 by 2012.

What Works Best for Mandy

The original oil that worked best was made with the strain Banana Kush. As a maintenance dose, she takes 2 drops of oil 2-3 times daily. She puts the drops on parchment paper and freezes them, then swallows them like small pills. While Mandy has never weighed her doses, starting small and slowly working to higher levels has been very effective for her.

HS outbreaks are painful in tender areas and may persist for years.

While there is no direct evidence connecting cannabis with HS, studies indicate significant potential for cannabinoid medicine. A 2013 study found that topically applied THC could attenuate allergic inflammation, which the researchers determined had “implications for the future development of strategies to harness cannabinoids for the treatment of inflammatory skin diseases.” An earlier study found cannabinoids may benefit psoriasis, which shares some similarities with HS.