In addition, more trials are needed to investigate its use for numerous other conditions, such as muscle-spasticity in multiple sclerosis, Alzheimer’s disease, substance-abuse treatment, and diabetes protection.
Conclusion: CBD is unlikely to be effective by itself for nausea and vomiting. The combination of THC and CBD does seem to be effective for nausea and vomiting.
Conclusion: CBD may help with depression but more trials are needed.
9. Nausea and vomiting
Many other studies, both on animals and humans, have overwhelmingly concluded that CBD has immunosuppressive and anti-inflammatory properties which may make it a good choice for some autoimmune conditions or inflammation-related complaints. 16
Beneficial effects on anxiety after taking CBD were reported in an observational study where 21 patients out of 400 had anxiety. 8
Animal studies have shown that CBD has a positive effect on serotonin levels in the brain, and serotonin. Low levels of serotonin are thought to play a key role in mood as well as pain. 11
Conclusion: CBD is beneficial for treating certain types of epilepsy.
Proponents claim that CBD oil can treat a wide variety of health problems, including:
Outside of these two disorders, CBD’s effectiveness in treating seizures is uncertain. Even with Epidiolex, it is uncertain whether the anti-seizure effects can be attributed to CBD or some other factor.
Part of this response could be explained by the way that CBD acts in the brain. In low doses, CBD may act as an agonist to several receptor sites, meaning it acts similarly to surrounding molecules that normally bind to the receptor, enhancing the signalling of those receptor sites. At higher doses, however, too much activity at the receptor site can lead to an opposite effect, negating the beneficial effects of CBD.
To avoid interactions, tell your doctor and pharmacist about all prescription, over-the-counter, herbal, or recreational drugs you are taking.
The tricky part is calculating the exact amount of CBD per milliliter of oil. Some tinctures have concentrations of 1,500 mg per 30 mL, while others have 3,000 mg per mL (or more).
And it is only likely to be prescribed for a small number of patients.
A prescription for medical cannabis would only be given when it was believed to be in your best interests, and when other treatments had not worked or were not suitable.
And some cannabis-based products are available on prescription as medicinal cannabis. These are only likely to benefit a very small number of patients.
What are the side effects?
It is licensed in the UK for people with MS-related muscle spasticity that has not got better with other treatments.
Generally, the more THC the product contains, the greater these risks are.
Nabiximols (Sativex) is a cannabis-based medicine that is sprayed into the mouth.
It’s likely most of these products – even those called “CBD oils” – will be illegal to possess or supply. There’s a good chance they will contain THC, and may not be safe to use.