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In 2017, a clinical study was conducted to analyse severity and outcomes of acute alcoholic pancreatitis in cannabis users. Patients were studied during the period from 2006 to 2015. Urine drug screen test for THC were performed to patients.
The disease can be very dangerous. The most common symptoms include upper abdominal pain radiating to the back, difficulty to breath without any pulmonary cause, persistent nauseas and vomiting, which are rarely improvement by medication. High levels of sugar in blood or urine can also be found, as well as an increase in cells of the immune system. Treatment includes nothing that can be ingested. Rehydration, pain killers and nutritional support by intravenous. Surgical attention might be indicated in some cases.
Today, data about cannabinoids and acute pancreatitis is conflicting, researchers are calling for new studies to better understand the molecular mechanism implicated in this painful and dangerous condition.
Cannabis and acute pancreatitis
 Goyal H, Guerreso K, Smith B, Harper K, Patel S, Patel A, et al. Severity and outcomes of acute alcoholic pancreatitis in cannabis users. Transl Gastroenterol Hepatol 2017; 2:60
Inflammatory response in the pancreas is an important factor in the development of the disease. The anti-inflammatory potential of cannabis has been an interested topic since the endocannabinoid system was discovered in mammalian. However, there is also clinical evidence of cannabis inducing acute pancreatitis.
 Sommermeyer, L. (1935). Acute Pancreatitis. The American Journal of Nursing, 35(12), 1157.doi:10.2307/3412015
Results demonstrated CBD treatment diminished TNF-alfa and IL-6. Both are pro-inflammatory proteins secreted mostly by T cells, macrophages, neutrophils and endothelial cells; all of these cells express endocannabinoid receptors on their structures. The presence of these receptors allows cannabinoids such as CBD to act on them and thus ameliorating pain and controlling acute pancreatitis.