It is believed that nausea is caused by an increase in serotonin. CBD binds to serotonin autoreceptors , inhibiting the release of serotonin. By reducing the amount of serotonin in the body, CBD may help control nausea.
In a study on cannabis and migraine headaches, the frequency of migraines in the 121 adults in the study was reduced from 10.4 to 4.6 per month with the use of medicinal cannabis. While this study is not related to concussion headaches and did not examine the use of CBD alone, it does paint a promising picture for the use of cannabinoids in treating headache pain.
CBD Oil for Brain Inflammation
A study from 1998 found CBD to actually prevent brain cell death in rats induced with glutamate neurotoxicity. The study showed that CBD, and even THC, were powerful antioxidants with neuroprotective qualities.
One way in which CBD oil may be able to repair damage caused by head trauma is through a process called neurogenesis , which is the growth and development of neurons, or nerve cells in the brain and nervous system. CBD has shown the potential to stimulate this brain process, where neurons regenerate in response to damage caused by injury or age.
The CBD Oil Review Serving Standard is 25 mg of CBD, taken twice daily
In the United States, the first big study on cannabinoid treatment for concussion is being done by the University of Miami which received a $16 million grant for the research. The study is a five-year, three-stage study that will “assess the effectiveness of a new cannabinoid-based pill to treat concussion injuries. This partnership aims to propel this research and potential treatment forward by using two classes of drugs in a combination that scientists believe will reduce brain inflammation and the immune response.” See also the Miami Herald article.
As reported in UHealth in July 2018, the “findings of a pre-clinical pilot study were recently released, and they show that the combination therapy improved the cognitive functions of animals, compared with those treated with a single vehicle. In addition, there were no adverse effects from either the combination therapy or the individual components.”
CBD products are extracted from hemp or marijuana, which are essentially the same cannabis plant but are cultivated differently, hemp plants being grown to contain less than 0.3% THC.
Some research focuses specifically on CBD (cannabidiol), which is the nonpsychoactive element of cannabis, and other research focuses on medical cannabis, with various ratios of CBD and THC (tetrahydrocannabinol). CBD is a nonpsychoactive cannabinoid, and THC is the psychoactive cannabinoid.
In Australia, the medical cannabis company Impression Healthcare began a new clinical trial in mid-2020 to access its new cannabinoid formula IHL-216A on “its ability to protect the brain against the main injury mechanisms which cause cell death and other negative consequences in the days and weeks following head trauma.” Impression will test IHL-216A with in-human and animal trials.