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cbd oil propranolol

To investigate the possible interaction of a beta adrenergic blocking agent and marihuana, six healthy experienced marihuana smokers received the two drugs separately and in combination. Propranolol (120 mg per os) reduced resting HR and BP; there were no changes in performance on tasks designed to test psychomotor speed, attention, memory and learning. Marihuana (10 mg delta9-THC), administered in smoke, induced the typical subjective state (“high”) with marked increases in HR, BP and conjunctival injection; it impaired performance on a learning test without significantly affecting attention. Pre-treatment with propranolol blocked effectively the cardiovascular effects of marihuana; it prevented the learning impairment and, to a lesser degree, the characteristic subjective experience.

Huestis MA, Boyd SJ, Heishman SJ, Preston KL, Bonnet D, Le Fur G, Gorelick DA: Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users. Psychopharmacology (Berl). 2007, 194: 505-515. 10.1007/s00213-007-0861-5.

Saito VM, Wotjak CT, Moreira FA: Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders?. Rev Bras Psiquiatr. 2010, 32 (Suppl 1): S7-14.

Lassaletta A, Martino R, Gonzalez-Santiago P, Torrijos C, Cebrero M, Garcia-Frias E: Reversal of an antihistamine-induced coma with flumazenil. Pediatr Emerg Care. 2004, 20: 319-320.

Conclusions

Our systematic searches revealed that articles on intoxication by cannabis are scarce and report results based on small samples. Future studies evaluating pharmacological interventions directed at the attenuation of the several acute effects induced by cannabis and at promoting greater knowledge regarding its actions are urgently necessary and opportune in the face of the increasing challenge posed by such an important public health problem.

Cannabis intoxication rarely leads to acute respiratory deficiencies. Such deficiencies are more likely to develop in cases of pre-existing pulmonary pathology or polysubstance use. The appropriate therapeutic approach in these cases requires aggressive measures that include ventilatory support and the specific management of alterations associated with metabolic acidosis, infections, bronchospasm, and agitation. The occurrence of isolated respiratory insufficiency caused by depression of the central nervous system induced by cannabis is associated with a better prognosis [37].

Crippa JA, Zuardi AW, Hallak JE: Therapeutical use of the cannabinoids in psychiatry. Rev Bras Psiquiatr. 2010, 32 (Suppl 1): S56-66.

Substance Abuse and Mental Health Services Administration SAMHSA: Office of Applied Studies: 1999-2000 National Household Survey on Drug Abuse. 2001, U.S. Department of Health and Human Services