Animal studies have shown that CBD has anti-inflammatory effects and works on the endocannabinoid and pain-sensing systems to relieve pain.
Beneficial effects on anxiety after taking CBD were reported in an observational study where 21 patients out of 400 had anxiety. 8
Conclusion: CBD may help with depression but more trials are needed.
Most studies investigating if CBD is beneficial at relieving nausea or vomiting, have used a combination of CBD and THC, rather than just CBD alone. A 2016 review found the combination to be either more effective or as effective as a placebo. 14
Conclusion: Topical CBD may help relieve inflammation and excessive sebum production associated with acne but more trials are needed.
Other studies find CBD helpful in reducing various psychiatric and medical symptoms like anxiety, insomnia and pain in patients with substance use disorders, indicating that CBD may be an effective treatment for opioid addiction. However, further studies are necessary.
CBD’s ability to calm is perhaps its most popular effect and the reason its use is so widespread. A 2017 study in the Brazilian Journal of Psychiatry tested the anxiety levels of 57 men in a simulated public speaking test. Some received a placebo while others received either 150 milligrams, 300 milligrams or 600 milligrams of CBD before their speeches. Those who received 300 milligrams of CBD experienced significantly reduced anxiety during the test compared to those who received the placebo. Interestingly, participants who received either 150 or 600 milligrams of CBD experienced more anxiety during the test than the 300 milligrams group.
5. Alleviate ALS Symptoms
In some instances, CBD can be used to treat epileptic seizures.
For starters, tests on human cells found that CBD helps reduce the effects of high glucose levels on other cells in the body, which typically precedes the development of diabetes and various complications. Researchers concluded that with further studies, CBD could have significant benefits when used in patients with diabetes, diabetic complications and plaque buildup in artery walls.
CBD is often extracted from the cannabis sativa plant in oil form and mixed with an inert carrier oil like hemp seed oil for consumption. In recent years, CBD oil has skyrocketed in popularity thanks to its purported calming effects. It can now be found in a range of products from simple oil tinctures to CBD-infused potato chips.
Researchers tested the efficacy of inhaled CBD on 24 cigarette smokers who wanted to quit smoking in a 2013 study  that lasted a week. Twelve of the participants who received CBD reduced smoking by about 40%, while the group who received a placebo saw no reduction in the number of cigarettes they smoked.
There is also a growing body of evidence that suggests that CBD could help slow the spread of aggressive cancer cells  for breast cancer and also facilitate cancer cell death  . However, research on this is still in its early stages.
Summary: Effective – Academic research proves that CBD can help reduce fear reaction or effects.
14.2 May Help Drug (Opioid) Withdrawal & Addiction
In 2018, the passage of the Farm Bill made it legal in the U.S to sell hemp and hemp-derived products. However, not all hemp-derived cannabidiol products are certified as legal.
Hence, though CBD and THC share almost the exact formula, they have a difference in the molecular structure that gives every compound unique medicinal properties. CBD has a hydroxyl group while THC has a cyclic ring that gets you high, while CBD, on the other hand, does not. Hence, CBD can moderate the effects of THC  by alleviating anxiety and stress, giving you clarity and not high.
According to researchers, current cannabis users, over 4600 test subjects had fasting insulin levels up to 26% lower than those who didn’t use cannabis. They also had higher levels of HDL cholesterol that helps protect against diabetes and 17% lower insulin levels of resistance.
Summary: Effective – Academic research proves that CBD can help reduce acne.