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Testers say the formula helped them manage everyday stress, recover from workouts, and calm down in the evenings.

Medterra’s oil provides the benefits of CBD without THC. The CBD isolate formula contains pure CBD and is made using a CO2 extraction method.

The formula is available in four concentrations: 15, 30, 45, and 75 milligrams of CBD per 1 milliliter servings, catering to both beginners and more experienced CBD users. The brand also offers free carbon-neutral shipping on all orders.

Best CBD Oil Spray: Plus CBD Original Formula Spray

Staci Gulbin, MS, MEd, RD, is a registered dietitian, freelance writer, health editor, and founder of LighttrackNutrition.com. She has been a registered dietitian with the Commission on Dietetic Registration since 2010 and has over a decade of experience in the nutrition and dietetics industry.

This content is for informational purposes only and does not constitute medical advice; it is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition and before consuming or using any of the products mentioned on this site.

The endocannabinoid system (ECS) regulates a number of other systems in the body by controlling the release of various compounds. The body's natural cannabinoids assist with this regulation by binding to CB1 receptors, as does CBD and other plant-based cannabinoids. That's why CBD is used by some people to help manage mood, sleep, and pain. CBD works indirectly in the ECS by inhibiting the inactivation of anandamide, which is a neurotransmitter.  This leads to activity on the CB1 receptors and the release of serotonin, also known as the "feel-good" hormone. As a result, CBD is sometimes used to reduce anxiety.

Every person will respond a bit differently to CBD oil, so no one product is going to be right for everyone. You may have to try different products, different CBD spectrums, and different forms of CBD to find a formula that works for you.

There have also been suggestions that CBD may aid in the treatment of cannabis and nicotine addiction. Further research is needed.

CBD oil may benefit those with drug addiction, suggests a 2015 review of studies published in Substance Abuse.

Nerve Pain

CBD oil can interact with certain medications, including some drugs used to treat epilepsy. CBD inhibits an enzyme called cytochrome P450 (CYP450), which metabolizes certain drugs. By interfering with CYP450, CBD may either increase the toxicity or decrease the effectiveness of these drugs.

However, the effect of CBD on each addiction type was often very different. With opioid addiction, for example, CBD showed little effect in minimizing withdrawal symptoms in the absence of THC. By contrast, CBD on its own appeared effective in minimizing drug-seeking behaviors in users of cocaine, methamphetamine, and other psychostimulant drugs.

Here are a few tips to help you find the best CBD oil:

CBD has been touted for a wide variety of health issues, but the strongest scientific evidence is for its effectiveness in treating some of the cruelest childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which typically don’t respond to antiseizure medications. In numerous studies, CBD was able to reduce the number of seizures, and, in some cases, it was able to stop them altogether. Videos of the effects of CBD on these children and their seizures are readily available on the Internet for viewing, and they are quite striking. Recently the FDA approved the first ever cannabis-derived medicine for these conditions, Epidiolex, which contains CBD.

CBD is readily obtainable in most parts of the United States, though its exact legal status is in flux. All 50 states have laws legalizing CBD with varying degrees of restriction, and while the federal government still considers CBD in the same class as marijuana, it doesn’t habitually enforce against it. In December 2015, the FDA eased the regulatory requirements to allow researchers to conduct CBD trials. Currently, many people obtain CBD online without a medical cannabis license. The government’s position on CBD is confusing, and depends in part on whether the CBD comes from hemp or marijuana. The legality of CBD is expected to change, as there is currently bipartisan consensus in Congress to make the hemp crop legal which would, for all intents and purposes, make CBD difficult to prohibit.

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Some CBD manufacturers have come under government scrutiny for wild, indefensible claims, such that CBD is a cure-all for cancer, which it is not. We need more research but CBD may be prove to be an option for managing anxiety, insomnia, and chronic pain. Without sufficient high-quality evidence in human studies we can’t pinpoint effective doses, and because CBD is currently is mostly available as an unregulated supplement, it’s difficult to know exactly what you are getting. If you decide to try CBD, talk with your doctor — if for no other reason than to make sure it won’t affect other medications you are taking.

CBD is commonly used to address anxiety, and for patients who suffer through the misery of insomnia, studies suggest that CBD may help with both falling asleep and staying asleep.

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