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hemp negative effects

Eating hemp seeds is not considered as unsafe as is ingesting the hemp leaves or other parts of the plant. But the seeds can cause mild diarrhea because of the high-fat content.

Many hemp products, including hemp oil, hemp milk, and hemp protein powder can be purchased at a health food store, or online.

Hemp oil is often used as a hair conditioner, a skin moisturizer. Some studies found that hempseed oil may improve dry, itchy skin and help symptoms of eczema, reducing the need for prescription medication.  

Possible Side Effects

What does hemp taste like?

Hemp oil can be used as a cooking oil and, just like any other type of healthy oil, can be added to foods such as salads, dips, and spreads.

Yes, hemp seeds are legal in the United States, but the seeds must contain a minimal amount of THC (the psychoactive component of the cannabis plant that gets a person high).  

Are hemp seeds legal to ingest in the U.S.?

Massi P, Solinas M, Cinquina V, Parolaro D. Cannabidiol as a potential anticancer drug. Br J Clin Pharmacol 2013;75(2):303-12. View abstract.

Morgan CJ, Das RK, Joye A, et al. Cannabidiol reduces cigarette consumption in tobacco smokers: preliminary findings. Addict Behav 2013;38(9):2433-6. View abstract.

Poklis JL, Mulder HA, Peace MR. The unexpected identification of the cannabimimetic, 5F-ADB, and dextromethorphan in commercially available cannabidiol e-liquids. Forensic Sci Int. 2019 Jan;294:e25-e27. Epub 2018 Nov 1. View abstract.

Special Precautions and Warnings

Barnes, M. P. Sativex: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain. Expert.Opin.Pharmacother. 2006;7(5):607-615. View abstract.

Campos AC, Moreira FA, Gomes FV, et al. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philos Trans R Soc Lond B Biol Sci 2012;367(1607):3364-78. View abstract.

Leino AD, Emoto C, Fukuda T, Privitera M, Vinks AA, Alloway RR. Evidence of a clinically significant drug-drug interaction between cannabidiol and tacrolimus. Am J Transplant. 2019;19(10):2944-2948. View abstract.

Valvassori SS, Elias G, de Souza B, et al. Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. J Psychopharmacol 2011;25(2):274-80. View abstract.

Frassinetti S, Moccia E, Caltavuturo L, et al. Nutraceutical potential of hemp (Cannabis sativa L.) seeds and sprouts. Food Chem. 2018;262:56-66. View abstract.

Pregnancy and breast-feeding: There isn’t enough reliable information to know if hemp is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Insufficient Evidence for

Mikulcová V, Kaspárková V, Humpolícek P, Bunková L. Formulation, characterization and properties of hemp seed oil and its emulsions. Molecules. 2017;22(5). pii: E700. View abstract.

Statement from FDA Commissioner Scot Gottlieb, M.D., on signing of the Agriculture Improvement Act and the agency’s regulation of products containing cannabis and cannabis-derived compounds. U.S. Food and Drug Administration Web site. Available at: https://www.fda.gov/news-events/press-announcements/statement-fda-commissioner-scott-gottlieb-md-signing-agriculture-improvement-act-and-agencys. (Accessed May 7, 2019).

Schwab US, Callaway JC, Erkkilä AT, Gynther J, Uusitupa MI, Järvinen T. Effects of hempseed and flaxseed oils on the profile of serum lipids, serum total and lipoprotein lipid concentrations and haemostatic factors. Eur J Nutr. 2006;45(8):470-7. View abstract.