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Some people may get diarrhea or liver problems [when using CBD]. This is dependent on the individual and their medical history, so monitoring is important,” says Dr. Matharu-Daley.

It’s important to point out that CBD is not regulated by the FDA and therefore dosages might not be accurate. It’s also difficult to know what an appropriate dose is the first time you try a new product.

Gastrointestinal Issues

Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital.

“CBD is not an intoxicating substance, whereas THC is a psychoactive that can get you high,” explains Dr. Jas Matharu-Daley, a physician and consultant for a brand that specializes in CBD production.

Also known as “cotton mouth,” CBD can potentially cause your mouth and eyes to feel very dry, notes Dr. Brent A. Bauer via Mayo Clinic. Though this side effect is more likely to occur with THC, it can happen with CBD, as well.

According to a 2012 study in the Journal of Experimental Medicine, rats injected with inflammatory chemicals in their hind feet experienced less inflammation and neuropathic pain when treated with an oral dose and spinal injection of CBD.  

Human studies evaluating the use of CBD in treating chronic pain are lacking. Those that do exist almost invariably include THC, making it difficult to isolate CBD’s distinct effects.

Heart Health

Clinical research has shown that CBD oil can trigger side effects. Severity and type can vary from one person to the next.

However, the effect of CBD on each addiction type was often very different. With opioid addiction, for example, CBD showed little effect in minimizing withdrawal symptoms in the absence of THC. By contrast, CBD on its own appeared effective in minimizing drug-seeking behaviors in users of cocaine, methamphetamine, and other psychostimulant drugs.

CBD oil may reduce the risk of heart disease by alleviating hypertension (high blood pressure) in certain people, suggests a 2017 study in JCI Insight.