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how cbd works

GPR55 has been dubbed an “orphan receptor” because scientists are still not sure if it belongs to a larger family of receptors. GPR55 is widely expressed in the brain, especially in the cerebellum. It is involved in modulating blood pressure and bone density, among other physiological processes.

How does CBD , an exogenous plant compound, get inside a human cell to bind to a nuclear receptor? First it has to pass through the cell membrane by hitching a ride with a fatty acid binding protein ( FABP ), which chaperones various lipid molecules into the cell’s interior. These intracellular transport molecules also escort tetrahydrocannabinol ( THC ) and the brain’s own marijuana-like molecules, the endocannabinoids anandamide and 2AG , across the membrane to several targets within the cell. CBD and THC both modulate receptors on the surface of the nucleus, which regulate gene expression and mitochondrial activity.

GPR55 —orphan receptors

CBDA [Cannabidiolic acid], the raw, unheated version of CBD that is present in the cannabis plant, also has a strong affinity for the 5- HT1A receptor (even more so than CBD ). Preclinical studies indicate that CBDA is a potent anti-emetic, stronger than either CBD or THC , which also have anti-nausea properties.

CBD binds to TRPV1 , which can influence pain perception.

Cannabidiol ( CBD ), a non-intoxicating component of the cannabis plant, has generated significant interest among scientists and physicians in recent years—but how CBD exerts its therapeutic impact on a molecular level is still being sorted out. Cannabidiol is a pleiotropic drug in that it produces many effects through multiple molecular pathways. The scientific literature has identified more than 65 molecular targets of CBD .

However, the endocannabinoid system can only regulate these areas when working properly. When this system fails, we see an increase in disease and disorders, like migraines, fibromyalgia, and IBS. Thanks to advances in medical science, we’ve discovered that when the body fails to produce enough of its own endocannabinoids, we may be able to supplement with plant cannabinoids.

Anandamide plays a role in mood regulation, boosting dopamine levels, which increase happiness and joy, reducing pain, managing stress, and regulating sleep, among many other bodily functions.

What’s the Endocannabinoid System made Of?

Anandamide functions as a neurotransmitter because it sends messages between nerve cells throughout the nervous system. It mostly affects the brain’s areas that influence pleasure, happiness, cognitive, sensory, and motor functions.

If you recall from reading about the Endocannabinoid System, CB1 receptors are found mainly in the Peripheral Nervous System (PNS), which consists of the brain and spinal cord. In comparison, the CB2 receptors are found in our Central Nervous System (CNS), which consists of our immune system and inflammation response.

Imagine a drug that has been used medicinally for over 8,000 years.