Is CBD Snake Oil

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On Thursday, November 5, and Monday, November 9, respectively, I attended "CBD: Wonder Ingredient or Potential Snake Oil?"—a virtual workshop that covered topics related to the cannabidiol (CBD) industry overthe course of two half-day sessions. Cannabidiol is a non-psychoactive (non-mind-altering) compound found in the cannabis plant— otherwise known as marijuana. The boom of the CBD industry begs the questions, what do CBD products really do? Is there any true benefit? Or is this just another ‘cash grab’? CBD (cannabidiol) has become a trend before scientists have even fully figured out how it works with our bodies. What will that mean for its future medical use and perception?

Workshop: “CBD: Wonder Ingredient or Potential Snake Oil?” A Student Perspective

On Thursday, November 5, and Monday, November 9, respectively, I attended “CBD: Wonder Ingredient or Potential Snake Oil?”—a virtual workshop that covered topics related to the cannabidiol (CBD) industry overthe course of two half-day sessions. Cannabidiol is a non-psychoactive (non-mind-altering) compound found in the cannabis plant— otherwise known as marijuana. The seminar could not have been timelier given the fact that on Tuesday, November 3, 2020, New Jersey voters approved Public Question 1, which legalizedthe use of adult recreational marijuana in the state—a decision that could boost the New Jersey economy by as much as $126 million annually. This event was made possible by the Rutgers University Center for Dermal Research and its esteemed director, Dr. Bozena Michniak-Kohn, and focused on issues ranging from regulation to manufacturing to intellectual property.

CBD: Wonder Ingredient or Potential Snake Oil? Day 1

To kick off this insightful event, Dr. Daniel Siegel, a clinical professor of dermatology at SUNY and Chief Scientific Officer (CSO) for the scientific advisory board of Greenway Therapeutics—a medically focused biopharma company—gave a presentation titled “Therapeutic Potential of Cannabinoids in Dermatology and Beyond.”

Siegel, along with Greenway Therapeutics president and CEO Michael Milane, MD, has pioneered a new product called Canno TM Cream, which features a nanoparticulate CBD cream that seems to be effective and fast-acting in reducing redness and inflammation of the skin.

Continuing the momentum from the first speaker, David Steinberg, president of Steinberg & Associates, a cosmetic regulatory consulting firm specializing in concept-to-market compliance for topical and OTC products, gave a comprehensive overview of the CBD regulatory landscape.

Next, Keith Woelfel, the director of research and development (R&D) for Caliper Foods, a consumer packaged goods (CPG) company, addressed a truly complex topic in his presentation “CBD: CMC (chemistry, manufacturing, and controls) Challenges.” He provided insight into a critical issue, which is the irregularity of testing for purity and extract percentages of CBD. Different labs may come up with different results, and the exact science for testing still needs to be refined, streamlined, and regulated into one singular system. Caliper has made it their mission to refine and master this process. Rounding out the first half-day session, Shahnam Sharareh, Esq., a patent attorney with , enlightened us about the many intellectual property issues surrounding the CBD industry.

Day 1: Summary – CBD can be a wonder ingredient if used for the right purposes. The industry is working its way through some regulatory struggles, which are exacerbated by companies making unchecked and unverified claims about the benefits of their products. By coming together and setting the best practices for testing and processing, the industry can head in the right direction.

CBD: Wonder Ingredient or Potential Snake Oil? Day 2

The second session on November 9 began with a panel discussion, “Corporate Banking, Employment, and Investment Considerations,’ which featured several partners of law firm Fox Rothschild LLP, which specializes (among other things) in cannabis law, environmental law, intellectual property, and regulatory and compliance issues . Moderated by Shahnam Sharareh, who also holds a doctorate in pharmacy (PharmD), panelists included attorneys Jonathan Lagarenne, who discussed corporate banking, Bob Nagle, who discussed employment and HR considerations, and Mark Yacura, who discussed regulatory and due-diligence considerations.

After a brief break, Fox Rothschild LLP partner Joshua Horn gave a comprehensive overview of the ever-evolving CBD landscape in his presentation “CBD Update on the Latest Importation, Transportation, and Intrastate Sales and the Ever-evolving Matrix of State Compliance Regulations,” and referenced industry stakeholders including the United States Department of Agriculture (USDA) and US Food and Drug Administration (FDA). The FDA has had to tighten restrictions on serious claims made by companies that produce CBD ingestible—statements such as, “this CBD tablet will cure your cancer!” However, they have not really tackled the topical field (lotions, creams, etc.).

A high-level view of the CBD process from farm to consumer.

In the final session, Robert Falcone, senior manager of regulatory affairs at Prestige Consumer Healthcare, outlined many FDA and USDA perspectives on CBD and hemp-derived CBD products. We explored how the 2014 Farm Bill initiated a pilot program for hemp growth and usage, and how the 2018 Farm Bill expanded upon that for commercial production. There are still many questions that remain about the safety of CBD, and Dr. Falcone posed some of the more interesting, intricate, and important questions that require research and clinical trials in order to answer.

Day 2: Summary While CBD can definitely be of use and is not outright harmful to the body, it is important to study every aspect of the chemical and how it may affect the body over a long period of time. Another amazing development in the world of CBD has been the approval of Epidiolex—the first CBD drug approved by the FDA which can be used for individuals with two subtypes of epilepsy that are commonly associated with seizures.

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Final Takeaways:

CBD has the potential to be a wonder ingredient that might be able to help with anxiety, pain, and skin disorders. However, the field is saturated with products that make false claims that—while harmless to the consumer (aside from the money they waste buying a product that has no benefits)—serve to discredit the true value and curative properties that many CBD produces may possess. In this sense, CBD can be a snake oil. More safety studies, tighter regulation, and investigation into how CBD works and helps in the body will help pave the way for CBD to distinguish its place as a medical therapy. In the meantime, there are a number of CBD products out there that can be a useful remedy, just make sure to do your due diligence and research as a consumer!

CBD, ‘Snake Oil’ or Life-Changing?

This week Volteface examines the emerging and seemingly booming CBD industry. In this piece we had the opportunity to discuss the topic with Paul Moore, patient advocate and Chief Executive Officer at Green Machine CBD. Moore discussed the vast potential applications and benefits that the CBD business offers to both the UK and Europe.

CBD is a non-psychoactive compound found in the cannabis plant. Unlike THC, CBD is legally sold over the counter as a wellness product or ‘novel food’. As aforementioned, due to not having psychoactive properties, CBD products will not get the user ‘high’. Whilst this classification as a novel food forbids companies from making medical claims, the product is licensed in two MHRA-approved medicines, Epidiolex and Sativex.

Whilst novel food companies cannot make medical claims, this has not stopped CBD users from reporting a plethora of benefits. Popular belief in this new-age medication is undeniable: In the first four months of 2020 alone we have witnessed £150 million pounds spent on CBD products in the UK alone. This interest in the emerging CBD industry is further reinforced by the 8 million British citizens who now buy CBD products.

CBD is now legal and available in over 10 countries including the UK and USA, while almost all other cannabinoids in the UK are controlled substances under the Misuse of Drugs Act 1971.

However, while this certainly indicates an interest in these products, this is far from evidence of their legitimacy. We have all seen the huge emergence of beauty and culinary CBD products in the UK, however what do these products really do? Is there any real benefit? Or is this just another industry ‘cash grab’?

Mike Power writing for the Guardian in 2019 refers to CBD salesmen as the “snake oil salesmen of the modern wild west” citing many examples of the undeniable ‘cash grabs’ which have emerged from the CBD industry. The most notable example was the sale of ‘CBD water’ sold in clear bottles resulting in the CBD swiftly degrading due to the sensitive nature of the compound.

By Power’s own admission, however, the health benefits of CBD (like THC) are undeniable as we have seen by not only the reforms in the UK but across the world.

The findings of this report have only been further reinforced by the animal testing of CBD products. As these studies indicated, CBD could be used to treat a multitude of medical conditions. These range from Alzheimer’s, Parkinson’s, Huntington’s disease and even a reduction in the growth of cancer.

It is important to highlight here that we live in a free market society. Thereby in any industry some ‘cash grabs’ will emerge, particularly when there is lots of money to be made. Thus these ‘cash grabs’ do not diminish the value of legitimate CBD brands. One such example of a legitimate CBD brand to flourish since the initial boom is CBD business Green Machine, run by Paul Moore.

Volteface spoke with Moore about how he became involved in the CBD industry and the challenges that CBD businesses in the UK face in 2021.

Moore began his journey in 2016 after he was diagnosed with rheumatoid arthritis. Doctors told Moore that his only option was strong steroids and treatment which would leave him hospitalised for 2 weeks every 2 months, as well as wheelchair bound just 6 months after starting his initial treatment.

Therefore, seeing the ludicrous physical cost of these treatments, Moore began investigating alternative forms of relief. This interest in turn led Moore to investigate the vast potential applications of cannabis-based medicines.

When exploring alternative medicines, Moore personally witnessed the vast power and application of cannabis-based medication through CBD. As previously mentioned, while other cannabinoids remain illegal in the UK, CBD is not and therefore Moore saw an opportunity to help others just like him in a legal and safe environment. Moore went on to open not only his first CBD store but additionally the UK’s first CBD dispensary in 2017.

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When opening a CBD business, Moore emphasises that his primary goal and intention is to support medical patients being failed by traditional clinical medical treatments. Moore also highlights the important role CBD businesses and their owners play in educating the public on cannabis-based medications and their legitimacy.

“When entering local communities Green Machine was met with the same criticism one would expect from opening a new cannabis based business. These complaints largely stemmed from parents considering me as some kind of ‘drug dealer’ accusing me of encouraging drug use. However rather than arguing with these individuals I would offer them to sign a petition for my shop’s removal. I did this under the condition they would sit down for a coffee and give me the opportunity to educate them on what my business does. If they were still unsatisfied, they were welcome to sign the petition.”

This education and patient-focused attitude have clearly succeeded as Green Machine is yet to have a single store removed. Additionally, Green Machine is now expanding to 13 stores by 2022. The company currently holds 10 stores across the UK with 7 located in London alone.

However, while Moore and his business have been met with huge success, unfortunately UK and global legislation makes running CBD business a difficult task. The first legislative obstacle highlighted by Moore is the ‘novel foods status’, where a novel food is defined by food.gov to be as follows.

The issue here is any food that is dubbed ‘novel’ as a result of this definition is then required to be authorised before they can be placed on the UK market. In order to gain approval a novel food therefore must follow one of the two routes retained under EU law, a traditional food notification or a full application.

As of 2019 CBD was classified a novel food and therefore any CBD extract products must apply for authorisation using the procedure for full applications outlined on the government website. This adds an additional challenge for CBD businesses in the UK; with ‘red tape’ and testing standards set so high, it is virtually impossible for small businesses to accommodate.

This is evident by the fact as of April 2021, over a year after the novel food applications were requested from CBD business; only three businesses have successfully qualified . Moore additionally highlights that this constant need to tamper with CBD-based products to render it acceptable for the novel food requirement diminishes the medicine’s efficacy..

“Think of it like frying broccoli. If you cake it in oil and fry it you’ve lost most of your nutritional benefits. In the same way if you put THC or CBD product’s through intense clinical processes you are losing some of the product’s benefits, for example in the UK when medical cannabis is blasted with ionising lasers resulting in worse quality cannabis for medical patients.”

Interestingly, while a patient advocate and Cancard holder, Moore was not always a cannabis advocate. In his younger years, he recalls friends and family being consumed by cannabis, and was subsequently apprehensive to engage with the drug. However, through research following his diagnosis it became increasingly clear that cannabis did not take his friends’ lives away- Rather the responsible party was outdated laws and legislation which have flooded UK streets with dangerous and poorly prepared drugs. We can see evidence of this thesis in a study conducted by King’s College London, which found that 95.9% of seized cannabis in London in 2016 was ‘Sinsemilla’ or ‘Skunk’.

When speaking with Volteface, Moore highlighted how the potential benefits of cannabis range far beyond the physical and mental health of individuals. Moore has now begun investigating how cannabis and hemp can be applied in sustainability efforts to craft a more environmentally friendly and sustainable future. These discoveries have come through his new venture ‘Viken Eco’.

Named after the beautiful village Viken in Sweden currently being damaged by the effects of climate change, this venture focuses on the vast sustainable applications of ‘hempcrete’ for both the construction of houses and their insulation. Moore will additionally be donating the proceeds from this venture to charities working to save animal habitats and building coastal erosion solutions.

Hempcrete is a sustainable substance made from the stem of hemp plants being mixed together with a binder. Hempcrete acts as an excellent building material as it can be both mixed on site and pre-cast off site to form blocks or panels. In addition to being very hard and self-supporting once set, hempcrete is not load bearing, due to the air trapped within the material and the slightly flexible nature of the hemp shiv aggregate. Hempcrete additionally holds a medium density, which means it provides both insulation and thermal mass within the same material.

Moore’s words and insights only further highlight how underused and explored the vast potentials of this plant are. Therefore, one can only conclude that to dub CBD as a ‘snake oil’ seems to ignore both clinical and academic evidence, and patient testimonials.

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Moore himself was told he would be left wheelchair bound just 6 months after his available NHS treatments, yet through the power of medical cannabis and CBD treatments, Moore has been able to continue not only walking but creating a life supporting and sustaining business.

This piece was written by Cameron Akerman-Roberts, tweets @AkermanCameron.

An amendment to this piece was made on December 3rd.

Are we turning CBD into snake oil?

B12 deficiency nearly caused my death in 2015; did you have any idea that’s something to worry about? Like me four years ago, you probably didn’t—and it’s largely due to a fellow known as “ Dr. Feelgood .” This charlatan popularized B12 in the 1960s, administering it in a decidedly not-medical fashion, giving it to those without a deficiency because of the energy boost it offered, often combining it with intoxicants and other substances.

CBD has become a trend before scientists have even fully figured out how it works with our bodies.

This eventually led to it culturally being thought of as a “snake oil,” or basically worthless and unnecessary medicine—which had unfortunate and severe effects on how it’s now treated by the medical community at large. And this happened despite the 1934 Nobel Prize in Medicine being awarded to the man who stopped the formerly frequent deaths of the deficiency, then known as pernicious anemia.

In our culture, we like things simple. Even though B12 deficiency was an extremely common cause of death a mere century ago, doctors are now hardly taught about it; they’re not even taught to screen for it correctly , and often not testing even serum levels unless they see anemia, a late-stage symptom that doesn’t happen in everyone.

Let’s talk about what this means for cannabis. CBD , or cannabidiol, is trendy. So trendy, it’s showing up at dinner parties , high-end juice bars , even Carl’s Jr. —and it’s at risk of falling into the same fate as B12.

The Big Deal

Within each and every one of us is a system of receptors that interact with cannabis, allowing us to experience its pleasurable and therapeutic effects. It’s called the endocannabinoid system , or ECS for short. Yet most doctors haven’t been taught about the endocannabinoid system at all, ever.

Despite the willful ignorance of the medical field in this regard, experts have been studying the ECS for nearly 30 years, understanding that it acts as a balancing force in all of the other bodily systems. Put simply, the ECS is an important biological network that medical professionals have yet to fully understand.

What if the result of CBD-mania could be that the medical prowess of the ECS, and the cannabinoids that interact with it, aren’t ever taken seriously?

Because it interacts with the other bodily systems to help achieve homeostasis (or balance), when the ECS isn’t functioning properly, it may affect the body in a multitude of ways , and often in a severe manner.

This is also why cannabinoids like CBD are such medical powerhouses—because they can help the ECS function when it can’t produce enough endocannabinoids (the cannabinoid-like compounds our body naturally produces) to run properly. Different cannabinoids in cannabis work with the ECS in a multitude of ways, empowering it to aid the cacophony of symptoms that can be caused by ECS imbalance.

The “Dr. Feelgoods” of CBD

By way of its effects on the ECS, CBD is a serious subject, and the way it’s regarded has very real implications. All of us need to start treating it appropriately, but especially medical professionals and those profiting from CBD. Since the passing of the Farm Bill , CBD has completed saturated our culture—and the pyramid schemes, ice cream flavors, and sketchy (untested!) products from random websites are affecting the way CBD is viewed.

The stigma around cannabis has already led to a major bodily system being largely ignored by the people who are responsible for protecting our health. CBD has become a trend before scientists have even fully figured out how it works with our bodies.

In our culture, if people think something is irrelevant, history has shown that it will be treated as so, regardless of overwhelming facts to the contrary. Even though the ECS was discovered in the early 90’s, its relation to a stigmatized plant means that it’s been ignored. Our nation has been swept up in the miraculous power of a cannabinoid without even really knowing what it is, or that there’s many more of them waiting to be studied and benefited from.

CBD has already proven to be an important medicine for serious conditions. But if we keep treating CBD with all the relevance of a fidget spinner, it’s hard to imagine that the dinosaur pace of cannabis science will hasten. This means that the lack of an even rudimentary test for endocannabinoid deficiency or dysfunction will persist, and people will continue to be diagnosed with “incurable” and misunderstood diseases—and still suffer the symptoms .

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