Conclusion: Topical CBD may help relieve inflammation and excessive sebum production associated with acne but more trials are needed.
In addition, more trials are needed to investigate its use for numerous other conditions, such as muscle-spasticity in multiple sclerosis, Alzheimer’s disease, substance-abuse treatment, and diabetes protection.
Anxiety scores decreased in a large case series of 72 patients, with 57 patients (79.2%) reporting decreased scores within the first month after CBD treatment. 9
31% of people taking CBD for other conditions such as anxiety or non-cancer-related pain reported improved sleep with CBD. 8
In a large case series of 72 people, 48 patients (66.7%) reported an improvement in sleep scores within the first month, but these fluctuated over time. 9
CBD can interact with other medications used for epilepsy and some serious side effects have been reported, notably, a decrease in liver function when given to people already taking valproate.
Conclusion: CBD is beneficial for treating certain types of epilepsy.
Other research (both animal and human) has shown that CBD has anti-inflammatory effects, and it may relieve pain by this mechanism.
CBD can interact with other medications used to treat heart conditions or immunosuppressants so you should always talk with your doctor before taking CBD.
Human studies evaluating the use of CBD in treating chronic pain are lacking. Those that do exist almost invariably include THC, making it difficult to isolate CBD’s distinct effects.
Among the few human trials evaluating CBD’s anxiolytic effects was one published in the Brazilian Journal of Psychiatry in 2019. For this study, 57 men were given either CBD oil or a placebo before a public-speaking event. Anxiety was evaluated using physiological measures (such as blood pressure, heart rate, etc.) and a relatively reliable test for mood states known as the Visual Analog Mood Scale (VAMS).
Scientists believe that CBD reduces nerve pain by binding to glycine receptors in the brain that regulate the speed at which nerve signals pass between nerve cells.
CBD oil may benefit those with drug addiction, suggests a 2015 review of studies published in Substance Abuse.
CBD oil is an extract of Cannabis indica or Cannabis sativa—the same plants that, when dried, make marijuana. CBD oil is believed by some to treat pain, reduce anxiety, and stimulate appetite in the same way that marijuana does, but without its psychoactive effects. CBD has also shown promise in treating certain types of seizures.