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side effects of cbd pills

Clinical research has shown that CBD oil can trigger side effects. Severity and type can vary from one person to the next.

Medical marijuana is frequently prescribed to people with intractable (treatment-resistant) pain, including those with terminal cancer. There is some evidence that CBD contributes to this benefit.

CBD is the short name for cannabidiol, one of the two chemicals—among the dozens in cannabis—that have the most health benefits. The other, tetrahydrocannabinol (THC), produces the psychoactive effects described as being “high.” CBD oil generally does not contain THC, although some trace amounts may be present in products sold in certain states.

Possible Side Effects

Part of this response could be explained by the way that CBD acts in the brain. In low doses, CBD may act as an agonist to several receptor sites, meaning it acts similarly to surrounding molecules that normally bind to the receptor, enhancing the signalling of those receptor sites. At higher doses, however, too much activity at the receptor site can lead to an opposite effect, negating the beneficial effects of CBD.

CBD oil may reduce the risk of heart disease by alleviating hypertension (high blood pressure) in certain people, suggests a 2017 study in JCI Insight.  

There is some evidence that CBD interacts with seizure medications such as Onfi (clobazam) and boosts their concentration in the blood. Further research is needed.

The tricky part is calculating the exact amount of CBD per milliliter of oil. Some tinctures have concentrations of 1,500 mg per 30 mL, while others have 3,000 mg per mL (or more).

CBD should be used according to the manufacturer’s instructions. A person should read and follow the label carefully. Use no more than instructed. Using more may increase the chance of side effects or it may cause other problems.

Studies are ongoing, but there is evidence that CBD may be effective in reducing anxiety, chronic (long-term) pain like back pain, and insomnia or trouble sleeping.

CBD Dosage

Other oral forms of CBD are edible gummies and capsules. Topical CBD may also be a lotion, cream, or balm.

Reviews and meta-analyses of cannabinoids found the following:

Many studies of CBD, including its side effects, are in their early stages. Most people tolerate CBD well.