The only thing that comes close is a Phase 2 clinical trial using a proprietary CBD transdermal gel (meaning it’s meant to go through the skin into the bloodstream) in 320 patients with knee osteoarthritis over 12 weeks, which has not been peer-reviewed to date. Unfortunately, in almost all of the study’s measures of pain, those who received CBD didn’t have statistically different scores from those who got placebo. But “they found some reductions in pain and improvements in physical function,” Boehnke says.
Then the researchers measured the inflammation in each rat’s knee joint, the level of CBD that made it into their bloodstream, and their pain-related behaviors. They found that the rats that were given the two highest doses of CBD showed significantly lower levels of inflammation and lower pain behavior scores compared to those that got the control. The two lower doses didn’t show much of an effect.
“There’s really no substitute for doing proper human studies, which are difficult, expensive, and ethically complicated,” Dr. Tishler says. And we simply don’t have them for CBD and pain.
Here’s what the research says about using CBD for pain.
But some studies have found essentially zero side effects of high-dose CBD (900mg) and those that researchers do see—like drug interactions—aren’t considered to be issues when CBD is used topically.
“It actually is a very promiscuous compound,” Kevin Boehnke, Ph.D., research fellow in the department of anesthesiology and the Chronic Pain and Fatigue Research Center at the University of Michigan, tells SELF. “It will bind to receptors in multiple different pathways,” which makes it difficult to know how it might cause noticeable effects.
The studies we do have about CBD for pain are all animal studies. For example, in a 2017 study published in Pain, researchers gave rats an injection into one of their knee joints to model osteoarthritis. Rats then either received doses of CBD or saline directly into an artery in the knee joint. Results showed that, after receiving CBD, rats showed less inflammation in the joint area and fewer pain-related behaviors (like shaking or withdrawing the affected paw or not being able to bear weight in that paw) compared to those that received saline.
Why does the body have receptors for compounds in cannabis? Well, it doesn’t exactly. Cannabinoids like THC and CBD are similar enough to compounds that your body naturally makes, called endocannabinoids, that they can interact with this system. Normally, the endocannabinoid system is thought to play a role in a variety of functions in the body, helping to regulate things like parts of the immune system, the release of hormones, metabolism, and memory.
They are not psychoactive and can be used to treat pain, inflammatory skin rashes, and bacterial skin infections.
Due to the fact that skin is the largest organ in your body, it makes sense to apply an effective nourishing topical lotion that will benefit you. Topically applied, CBD and its other ingredients can have this amazing effect!
topical benefits of CBD Cream & CBD lotion
Topical CBD seems to be one of the most versatile applications for this already very versatile compound.
The endocannabinoid system is thought to play an important role in the immune response of our skin.
Cannabis extracts have been used topically to relieve pain and treat skin rashes in India and Latin America for hundreds of years.
If you are new to cannabis, fret not! Using a topical CBD oil is easy. There are two key ways that topical CBD oil works to reduce discomfort and normal inflammation. First, the oil contains what are called phytocannabinoids, also known as cannabinoids, which interact directly with our endogenous endocannabinoid system (ECS). When you use topical cbd, the cannabinoid penetrates deep into the tissue where applied, saturating the ECS so that the precursors for discomfort and normal inflammation are reduced. The ECS is a system of receptors (CB1 & CB2) throughout our body that manages various biological functions. CBD naturally raises the endocannabinoids in your body, helping to relieve discomfort. CBD helps limit your body’s normal inflammatory response when you have muscle soreness due to exercising or lifting weights. By working with the natural functions in your body, CBD provides a calming effect for both your mind and body. When taken regularly topical cbd oils can help make you more comfortable, whether you have aches and soreness or need to unwind after a long day.
In the case of a cbd topical, they are designed to provide targeted comfort by letting cannabinoids penetrate the skin and interact with our endocannabinoid receptors. A CBD topical can help with flexibility and mobility to the joints, soothe sore muscles or muscle tension, or help with other areas of the body. Because the cannabinoids do not enter the blood stream directly, effects are localized and intoxication doesn’t occur. Results can sometimes be felt within minutes and can last anywhere from two to four hours. Most people don’t experience any intoxicating effects from taking Papa & Barkley’s Hemp CBD products, however, every person’s body responds differently to cannabinoids. As always, it is better to start low and go slow as well as seeking the advice of a medical professional before starting a new health regimen.
How to Use a CBD Topical
The entourage effect—the idea that molecules that occur together in nature interact in useful ways — applies to cannabinoids and terpenes. Terpenes are molecular compounds that are naturally found in plants and insects, manifesting most often in the forms of natural oils, and are accompanied by a distinct aroma and viscosity. Terpenes and cannabinoids (such as CBD and THC) work together to maximize benefits in the body. Lab and patient-based studies reveal that while CBD or THC can work alone for some symptoms, they can often create better outcomes in combination. Specific ratios, especially with naturally occurring terpenes, have the potential to cause even better effects. The entourage effect is one of the leading theories influencing cannabis research worldwide.
Topical CBD can come in several forms – like a body oil, balm, lotion, or even a patch. There are even CBD-infused bath salts and soaks to give you full-body comfort. When you have an area of the body where you are feeling discomfort, you can use topical CBD the way you would a lotion to help reduce stress, discomfort, and normal inflammation. The great thing about topical CBD oil is that it doesn’t enter the bloodstream when you apply it, meaning it just targets the specific area you apply it to. To ensure a body oil works to the best of its abilities, you need to apply it liberally. Our skin is designed to all topicals from entering the body, so if you choose a product with a high concentration of CBD, make sure you apply enough to sink into your skin’s and provide the best results. Side note: if you’re using it in the bath, follow the product instructions for how long you should soak to really reap the benefits.
There’s a CBD topical product for everyone. Are your knees sore from that 10-mile run? Rub on some CBD Releaf Balm to soothe aching joints. Got tight muscles from sitting or standing all day long at your desk? You deserve a massage! Liberally apply CBD Releaf Body Oil to the places you need it most. And if you’re dealing with dry, irritated skin? Moisturize with our CBD Releaf Body Lotion! CBD topicals are the perfect way to embrace the world of cannabis wellness without the intoxicating effects of THC!