Sleep can be disrupted for many reasons, including depression. Rodents seemed to adapt better to stressful conditions and exhibited less depressive-like behavior after taking CBD, according to a review in Journal of Chemical Neuroanatomy. “Surprisingly, CBD seems to act faster than conventional antidepressants,” wrote one of the authors of a new review, Sâmia Joca, a fellow at the Aarhus Institute of Advanced Studies in Denmark and an associate professor at the University of São Paulo in Brazil, in an email interview. Of course, it’s difficult to detect depression in animals, but the studies that Ms. Joca and her colleagues reviewed suggested that in models of chronic stress exposure, the mice and rats treated with CBD were more resilient.
Up in the wee hours of the night, stuck watching videos of puppies? CBD may be promising as a sleep aid; one of the side effects of the Epidiolex trials for epilepsy was drowsiness, according to Mr. MacKillop, a co-author of a review on cannabinoids and sleep. “If you are looking for new treatments for sleep, that may be a clue,” he said.
Recently, the F.D.A. sent a warning letter to Curaleaf Inc. about its “unsubstantiated claims” that the plant extract treats a variety of conditions from pet anxiety and depression to cancer and opioid withdrawal. (In a statement, the company said that some of the products in question had been discontinued and that it was working with the F.D.A.)
Tips for Better Sleep
By Dawn MacKeen
But he cautions that the side effects could have been because of an interaction with other medications the children were taking to control the seizures. So far, there hasn’t been a randomized, placebo-controlled, double-blind trial (the gold standard) on sleep disorders and CBD.
Facts about wellness.
take your money?
A paper published by the World Health Organization found that “in humans, CBD exhibits no effects indicative of any abuse or dependence potential.” However, there may still be some unwanted side effects. While research has found that CBD has a much better side effect profile compared with most other drugs, a large dose of CBD can still have potentially adverse effects. For example, a2017 study published in the journal Cannabis and Cannabinoid Research concluded that while CBD had a “favorable safety profile,” there were side effects reported by participants, including tiredness, diarrhea, and changes in appetite or weight.
You may have heard about the various purported health benefits of this non-intoxicating cannabinoid, but how does CBD feel once it enters your system? Many consumers and medical patients report several positive effects after taking CBD, including feelings of relaxation and calmness. But the exact feeling you’ll get from CBD is contingent on several factors, including the type of CBD product, the total CBD dosage, and your ECS.
Not only does it depend on the individual, but also the individual’s ailment or health condition. Depending on an individual’s therapeutic needs, different CBD products may prove more beneficial than others.
CBD isolate is the most refined form of the non-intoxicating cannabinoid, containing upwards of 99% pure CBD. Photo by: Gina Coleman/Weedmaps
CBD may cause other side effects in some individuals, including nausea and irritability. Dr. Peter Grinspoon, a primary care physician at Massachusetts General Hospital and contributor to the Harvard Health Blog, discussed these potential side effects in a 2018 post, writing, “Side effects of CBD include nausea, fatigue, and irritability.”
Aside from CB1 receptors, CBD interacts with the human body by binding to several other targets. For instance, this non-intoxicating cannabinoid has at least 12 sites of action in the brain and may elicit therapeutic effects by activating multiple pathways at once.
Industrial hemp plants are typically grown for their fiber and seeds. Hemp plants are considered legal under US law, as long as they contain no more than 0.3% THC. Therefore, hemp-derived CBD products have little to no THC, which prevents consumers from feeling any intoxicating effects.